Blood Products From Mesenchymal Stem Cells |
• A
method of differentiating mesenchymal stem cells (MeSCs) to produce
blood products in vitro • The produced blood products can be used to treat a large number of diseases • Useful for patients with allergic and autoimmune reactions to donated blood products • Autologous donor MesScs or allogenic donor MesSCs may be used |
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Ex-Vivo Pigskin Wound Model |
• Alternative
to animal trials • Cost effective model for testing raw materials and active substances, wound dressings and transplanted cells • Very Similar to human skin |
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“Re-Useable” Antibodies (with Reversible Affinity) |
• Re-Useable
Antibody Breakthrough (for the purification of substances) • Switchable affinity technology based on allosteric modulation • Ultra-mild ellution conditions preserve the integrity of both the target substance and the antibodies • Offers a significant improvement in both efficiency and cost • Suitable for Affinity Chromatography Kits or Process Scale Purification |
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Genotyping of Degraded & Low Copy DNA Samples |
• BioPlex-11
multiplex PCR system provides an accurate solution for analysing
degraded and low copy DNA samples • Allows simultaneous analysis of ten short amplicon STR systems for a single aloquot • May be applicable for the analysis of telogen hair roots • German Patent Application, international applications possible |
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Fusion Proteins as Prodrugs in Tumor Therapy |
• Therapeutic
treatment of cancer and infectious diseases as well as autoimmune
deficiencies • Particularly suited to solid tumors as well as angiogenesis in pathological lesions • Antitumor activity is only activated in the diseased tissue (“prodrug”) • A range of cytokines of the TNF family may be used, including TNF, FasL, TRAIL, CD40L and LIGHT • Status: PCT Application Pending |
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Neuroglobin: a Novel Vertebrate Globin |
• Applicable
to neurodegenerative diseases (eg, Alzheimer's / Parkinson's) |
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CTL Cream Vaccine Treatment for Cancer and Persistent Virus Infections |
• CTL Cream Vaccine with relevance to cancer
and persistent virus infections • Cytotoxic T Lymphocyte cream experimentally successful in activating T-cells • Induction of a potent immune response exclusively against the target epitope • May provide new treatment options for Cancer and persistent virus infections like CMV and Human Papilomavirus |
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Oligopeptides for Cancer Immunotherapy |
• New & specific oligopeptides derived
from TAA (tumor-associated antigens) • Application as an immunotherapy for tumor patients, and as targets for adoptive T-cell, or T-cell receptor transfer • Suitable for the most sensitive and reliable immunomonitoring techniques • Synthesis and purification of oligopeptides are safe and cost effective |
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Site-Directed Mutagenesis of T-Cell Receptors |
• Biochemical synthesis of gene-modified
antigen-specific T-lymphocytes • Novel approach to immune therapy for cancer / virus diagnosis & prevention • Both individual and general tumor therapy applicable • Antigenicity and rejection of the modified therapeutic molecule minimised • IP Status: German & International patent application |
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Ultra-High Resolution ‘Optical-Nanoscopy’ |
• Breakthrough in ultra-high resolution opticial
microscopy (fluoroscopy) • A major improvement in resolution compared to existing optical techniques • Particularly beneficial for investigating fine biological structures (which can be damaged by electron-based techniques) • Retrofitting of conventional quantitative fluorescence microscopes possible |
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In Situ Microscope Probe Utilising SLD Illumination and Multimode Optical Fiber |
• Process Microscopy innovation for moving
particles in liquids or gases • Combined SLD illumination (super-luminescent diode technology) with multi-mode optical fiber reduces interference and improves image quality • Suitable for automatic image analysis (for online concentration and morphology measurements) |
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CW (Continuous Wave) Dye Laser based on a Polymer Disc |
• The World's first CW solid state dye laser • Tunability >40nm / CW output of 20mW, with a threshold ~ 500mW • Significant advantages over liquid solvent based lasers • Ease to handle (the lasing medium is sandwiched between two DVDs) |
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Automated Expirogram Solution for Improved Analysis of Airway Function |
• First automated expirogram solution providing
stable real-time monitoring of lung parameters on a breath-by-breath
basis • Available for implementation as an off-line analyzer or as an internal module incorporated into a conventional spirometry or capnography instrument |
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Suction Stent for the Protection of Gastro-Intestinal Anastomoses |
• Surgical implant for protecting gastro-intestinal
wounds from leaky sutures • Suction stent prevents anastomoses from exposure to gastric material • Elimination of post-operative infections and peritonitis • Mild vacuum conditions known to accelerate wound healing significantly |
